These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Pathogenesis of liver fibrosis. Synthesis of collagen and non-collagen proteins in cell culture and in vivo].
    Author: Ramadori G.
    Journal: Z Gastroenterol; 1992 Mar; 30 Suppl 1():17-20. PubMed ID: 1449011.
    Abstract:
    In vitro and in vivo studies have shown that Ito-cells are able to express the "smooth-muscle"-isoform of alpha-actin which seems to characterize the activated stage of the cells. "Activated" Ito-cells synthesize and secrete collagen- and non-collagen components of the extracellular matrix like fibronectin, laminin, tenascin and entactin. "Quiscent" Ito-cells synthesize mostly collagen type IV and III while "activated" Ito-cells also synthesize alpha-2-macroglobulin, a potent protease inhibitor. The in vitro obtained results were confirmed in vivo as demonstrated on liver sections from chronically damaged liver (carbon tetrachloride administration) by immunohistochemistry and by in situ hybridisation technique. Sinusoidal endothelial cells were shown to synthesize collagen type IV and fibronectin during the time in culture.
    [Abstract] [Full Text] [Related] [New Search]