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  • Title: [Alcohol drinking behavior based on the neurochemical background. I. Alcohol preference and brain monoamines].
    Author: Mizohata K.
    Journal: Arukoru Kenkyuto Yakubutsu Ison; 1992 Oct; 27(5):553-62. PubMed ID: 1449414.
    Abstract:
    The relationship between voluntary alcohol consumption and monoamine levels was studied in the inbred strains of C57BL/6N, C57BL/6J, A/J, BALB/cA, CBA/N, C3H/He and DBA/2Cr mice; the congenic mouse strain B10. Br/Sg, and the senescence accelerated mouse (SAM P1, SAM P2). C57BL strains exhibited a high alcohol preference whereas the other strains exhibited a low alcohol preference. A clear positive relationship was found between alcohol intake (g/kg/day) and brain norepinephrine (NE) level (r = 0.683, p < 0.05), and a clear negative relationship between alcohol intake and brain serotonin (5HT) level (r = -0.628, p < 0.05). These results suggest that a voluntary alcohol intake in mice is genetically influenced with the brain monoamines, and depend upon the levels of brain NE and 5HT.
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