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  • Title: Inhibition of adenosine deaminase by azapurine ribonucleosides.
    Author: Shewach DS, Krawczyk SH, Acevedo OL, Townsend LB.
    Journal: Biochem Pharmacol; 1992 Nov 03; 44(9):1697-700. PubMed ID: 1449528.
    Abstract:
    We have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but did not lower the Ki value for coformycin. Evaluation of these compounds in a MOLT-4 growth assay revealed that 2-azacoformycin was as effective as 2'-deoxycoformycin in potentiating growth inhibition by 2'-deoxyadenosine. The azapurine nucleosides merit further study as antitumor agents.
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