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  • Title: Protective effect of dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) against carcinogen-induced rat liver nuclear DNA damage.
    Author: Qing W, Liu G.
    Journal: Biomed Environ Sci; 1992 Sep; 5(3):201-7. PubMed ID: 1449655.
    Abstract:
    The protective effect of DDB against carcinogen-induced DNA damage was examined in the present investigation. Preincubation of rat liver nuclei with DDB (1 mmol.L-1) resulted in 60% inhibition of binding of 3H-benzo(a)pyrene to nuclear DNA. Unscheduled DNA synthesis (UDS) induced by aflatoxin B1 (10(-7) mol.L-1) in freshly isolated rat hepatocytes was also inhibited by DDB (10(-6)-10(-3) mol.L-1). Oral administration of DDB at 200 mg.kg-1 once daily for 3 d induced a significant increase of liver cytosol glutathione-S-transferase and microsomal UDPG-transferase activity in mice. These results indicate that DDB is able to directly or indirectly antagonize certain carcinogen-induced DNA damages.
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