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  • Title: [Anxiolytic effect of the dehydroepiandrosterone sulfate: mu-opioid mechanism].
    Author: Ovsiukova MV, Kudriavtseva NN, Obut TA, Amikishieva AV.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2003 May; 89(5):598-604. PubMed ID: 14502980.
    Abstract:
    Effects of dehydroepiandrosterone sulfate (DHEAS, 30 mg/kg, i/p, 4 and 28 hours after injection) on CBA/Lac male mice with increased level of anxiety resulting from chronic (20-days) social confrontations in two behavioral anxiety-estimated tests, were studied. The anxiolytic effect of DHEAS was discovered within 4 hours after injection in the "partition test" of social interactions and within 28 hours in "plus-maze test". Naltrexone (0.25 mg/kg, for 20 min before DHEAS injection) blocked this effect.
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