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  • Title: No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes.
    Author: Marino C, Giorda R, Vanzin L, Molteni M, Lorusso ML, Nobile M, Baschirotto C, Alda M, Battaglia M.
    Journal: Eur Child Adolesc Psychiatry; 2003 Aug; 12(4):198-202. PubMed ID: 14505070.
    Abstract:
    Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of whom had comorbid ADHD. No evidence of either association or linkage disequilibrium was found, neither in the total sample nor in the comorbid subgroup. Negative results do not support a common genetic basis between these two disorders for these markers.
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