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  • Title: A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp.
    Author: Chevallier C, Richardson AD, Edler MC, Hamel E, Harper MK, Ireland CM.
    Journal: Org Lett; 2003 Oct 02; 5(20):3737-9. PubMed ID: 14507218.
    Abstract:
    [structure: see text] The crude methanol extract of a marine sponge Cymbastela sp. collected in Papua New Guinea was selected for chemical investigation due to its significant cytotoxicity. Fractionation of the extract led to the isolation of jaspamide (1), hemiasterlin (2), milnamide A (3), and a new metabolite, milnamide D (4). The structure was solved by interpretation of NMR and mass spectra data. The cytotoxic and antitubulin activities of milnamide D (4) were evaluated.
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