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  • Title: The COP9 signalosome: an alternative lid for the 26S proteasome?
    Author: Li L, Deng XW.
    Journal: Trends Cell Biol; 2003 Oct; 13(10):507-9. PubMed ID: 14507477.
    Abstract:
    Two groups have recently reported ubiquitin-deconjugating activities associated with the COP9 signalosome (CSN). Together with a previously identified deneddylation activity, CSN now appears to possess biochemical activities towards the cullin-containing ubiquitin ligases (e.g. deneddylation) and ubiquitinated protein substrates in the proteasome-mediated degradation processes (e.g. deubiquitination). Here, we discuss how these findings support a central role for CSN in ubiquitination of substrate proteins and their proteolysis
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