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  • Title: A continuing signal maintains NGF receptor expression in hypoglossal motor neurons after crush injury.
    Author: Greeson DM, Moix L, Meier M, Armstrong DM, Wiley RG.
    Journal: Brain Res; 1992 Oct 30; 594(2):351-5. PubMed ID: 1450963.
    Abstract:
    Inhibition of axonal transport by vincristine applied to hypoglossal nerves 7 days after crush injury turns off the usual injured-induced expression of low affinity nerve growth factor receptor (p75NGFr). Vincristine applied proximal but not distal to the crush prevents p75NGFr induction. These results indicate that a continuing signal is axonally transported from the crush site that induces and maintains p75NGFr expression by injured motor neurons.
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