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  • Title: Stereo-defined synthesis of 5'-(Z)-substituted 4',5'-unsaturated adenosines and evaluation of their inhibitory activity against S-adenosyl homocysteine hydrolase.
    Author: Kumamoto H, Onuma S, Tanaka H, Kitade Y.
    Journal: Nucleic Acids Res Suppl; 2003; (3):13-4. PubMed ID: 14510356.
    Abstract:
    A new approach was developed for the synthesis of 5'-(Z)-substituted 4',5'-unsaturated adenosines, potential inhibitors against S-adenosyl-L-homocysteine hydrolase (SAHase). A highly stereoselective radical-mediated sulfur-extrusive stannylation was employed as a key step in the present approach. Inhibitory activity of the compounds against SAHase is also presented.
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