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  • Title: Lymphomatoid papulosis associated with mycosis fungoides: a study of 21 patients including analyses for clonality.
    Author: Zackheim HS, Jones C, Leboit PE, Kashani-Sabet M, McCalmont TH, Zehnder J.
    Journal: J Am Acad Dermatol; 2003 Oct; 49(4):620-3. PubMed ID: 14512906.
    Abstract:
    BACKGROUND: Although an association of lymphomatoid papulosis (LyP) with mycosis fungoides (MF) is recognized, our understanding of this relation is limited. OBJECTIVE: We sought to document the clinical experience at the University of California, San Francisco, in 21 patients who had both LyP and MF and to do clonality studies in 7 of those patients in whom this was possible. METHODS: We conducted chart review of the 21 patients and analysis for T-cell receptor-gamma gene rearrangements by the polymerase chain reaction. RESULTS: Of 54 patients, 21 (39%) with LyP had associated MF. LyP preceded MF in 14 (67%), MF preceded LyP in 4 (19%), and there was concurrent appearance in 3 (14%). Of the 21 patients, 20 (95%) were type A and only 1 (5%) was type B. An identical clone was found in lesions of both LyP and MF in all 7 patients in whom analysis was possible. CONCLUSION: Findings of this study strengthen the idea that LyP and MF are related T-cell lymphoproliferative disorders.
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