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  • Title: Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain.
    Author: Dietera A, Hamm A, Fiedler HP, Goodfellow M, Müller WE, Brun R, Beil W, Bringmann G.
    Journal: J Antibiot (Tokyo); 2003 Jul; 56(7):639-46. PubMed ID: 14513907.
    Abstract:
    A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.
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