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  • Title: Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.
    Author: Punthakee Z, Legault L, Polychronakos C.
    Journal: J Pediatr; 2003 Sep; 143(3):402-5. PubMed ID: 14517528.
    Abstract:
    Prednisolone has unknown growth-suppressing effects relative to other steroids. We retrospectively studied 9 children (6 with congenital adrenal hyperplasia, CAH) receiving hydrocortisone replacement after switching to prednisolone (dose ratio, 1:5). Growth velocity and, in patients with CAH, 17-OHP decreased significantly. Dose reduction reversed these effects. Roughly, growth suppression relative potency for prednisolone:hydrocortisone was 15:1.
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