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  • Title: Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes.
    Author: Gomez-Muñoz A, Hatch GM, Martin A, Jamal Z, Vance DE, Brindley DN.
    Journal: FEBS Lett; 1992 Apr 13; 301(1):103-6. PubMed ID: 1451777.
    Abstract:
    Incubation of hepatocytes with okadaic acid displaced the N-ethylmaleimide-sensitive phosphatidate phosphohydrolase from the membrane fraction into the cytosol and partially prevented the oleate-induced movement of phosphohydrolase from cytosol to membranes. However, higher concentrations of oleate still caused translocation and activation of the phosphohydrolase. This enzyme is stimulated by Mg2+, and is probably involved in glycerolipid synthesis. Okadaic acid also decreased the concentration of diacylglycerol within the hepatocytes. Okadiac acid had no observable effect on the activity of an N-ethylmaleimide-insensitive phosphatidate phosphohydrolase which remained firmly attached to membranes. This activity is not stimulated by Mg2+ and is probably involved in signal transduction by the phospholipase D pathway.
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