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  • Title: [Myelofibrosis in patients with chronic myeloid leukemia treated with interferon-alpha].
    Author: Kumas Sotiris, Semenova EA, Turkina AG, Zakharova AV, Domracheva EV, Khoroshko ND, Frank GA.
    Journal: Arkh Patol; 2003; 65(4):9-12. PubMed ID: 14518186.
    Abstract:
    Trepanobiopsies of the bone marrow were studied in 46 patients in a chronic phase of chronic myeloid leukemia in different periods after the beginning of interferon-alpha therapy. Progression of myelofibrosis was observed in 2 cases only. Regression of myelofibrosis was observed in 14 cases of 29 (34.2%). A negative correlation between reticulin myelofibrosis and response to therapy was found. Disappearance of diffuse reticulin myelofibrosis in all cases was followed by a cytogenetic response.
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