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  • Title: [Significance of regulatory peptide GRP for microcirculation of the small intestine after ischemia/reperfusion].
    Author: Heuser M, Gralla O, Nustede R, Post S.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1998; 115(Suppl I):105-7. PubMed ID: 14518222.
    Abstract:
    With the use of intravital fluorescence microscopy we demonstrate, that GRP in pharmacological doses reduces ischemia/reperfusion injury in the rat. As mechanism we discuss a precapillary vasodilation that has a protective effect on the capillary system downstream. A direct influence on leukocyte-endothelium interaction in post-capillary venules could not be shown. In addition, we show that even the GRP endogenously released plays an important role for the regulation of microvascular perfusion after ischemia/reperfusion injury.
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