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  • Title: [Influence of selective versus nonselective inhibitors of nitric oxide synthases on synovial microcirculation of the knee joint of the mouse in vivo].
    Author: Veihelmann A, Krombach F, Refior HJ, Messmer K.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1998; 115(Suppl I):197-201. PubMed ID: 14518242.
    Abstract:
    Nitric oxide production by the inducible NO-synthase in the synovium and chondrocytes is known to be enhanced during chronic joint inflammation and aseptic loosening of joint prostheses. Due to the distinct side effects of non-selective NO-inhibitors on the macro- and microhemodynamics, we investigated the in vivo changes after selective (N-iminoethyl-L-lysine (NIL)) versus non-selective NO-synthase inhibition (NG-nitro-L-arginine methyl ester (L-NAME)) in the synovium of the mouse knee joint. Our results show a significant decrease in the functional capillary density and an increase in the leukocyte accumulation after L-NAME injection. In contrast, NIL did not alter the microhemodynamics or the leukocyte-endothelial cell interaction in the synovium, indicating its potential use for therapeutic selective inhibition of iNOS in joint inflammation.
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