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  • Title: [Lack of effect of EGF on epithelial barrier function in experimental TNBS colitis].
    Author: Runkel N, Rohweder J, Kruschewski M, Fromm M, Schulzke JD, Buhr HJ.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1998; 115(Suppl I):217-21. PubMed ID: 14518247.
    Abstract:
    This study tested the hypothesis that EGF has a protective effect on the intestinal barrier function in experimental TNBS-induced colitis. EGF was given intraperitoneally one hour before and 24 hours after induction of colitis. The rats were killed 48 hours after induction of colitis: The distal colon was resected and mounted into Ussing chambers. Flux measurements were performed for Na+ and mannitol, and epithelial and subepithelial resistances were determined. A semiquantitative histological score was used to grade acute and chronic inflammation. Compared to controls, TNBS caused a 3-fold increase in both fluxy, indicating enhanced paracellular permeability. There rates was a severe reduction of total and epithelial resistances indicating a dramatic defect of epithelial barrier function. EGF failed to improve the electrophysiologic and histologic parameters. Therefore, EFG has no protective effective in experimental TNBS colitis.
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