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  • Title: [Determination of vascular endothelial growth factor (VEGF) concentration in serum of patients with colorectal carcinoma].
    Author: Broll R, Erdmann H, Windhövel U, Duchrow M, Strik MW.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1998; 115(Suppl I):315-8. PubMed ID: 14518267.
    Abstract:
    The aim of our study was to determine the serum concentration of VEGF in 53 patients with a colorectal carcinoma and 22 healthy volunteers (control group) and to compare it with tumor stage and volume. We found significantly higher serum levels in tumor patients in contrast to the control group and between patients with and without distant metastases. There was also a correlation between high serum concentrations and great tumor volumes, but only weak with tumor stage. Our results support the hypothesis that tumor growth is dependent on angiogenesis and that VEGF is a potent growth factor with angiogenic activity.
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