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  • Title: [Reduction of local and systemic complications of acute pancreatitis by monoclonal antibody to ICAM-1].
    Author: Werner J, Hartwig W, Schmidt E, Gebhard MM, Herfarth C, Klar E.
    Journal: Langenbecks Arch Chir Suppl Kongressbd; 1998; 115(Suppl I):725-9. PubMed ID: 14518349.
    Abstract:
    The prognosis of acute necrotizing pancreatitis is dependent on systemic complications. The endothelial adhesion molecule ICAM-1 mediates both leukocyte adhesion and migration. Expression of ICAM-1 was investigated at various time points in mild and severe necrotizing pancreatitis in the pancreas, lungs and intestine. A possible therapeutic effect of monoclonal antibodies against ICAM-1 was evaluated in severe necrotizing disease. The expression of ICAM-1 preceded the fulminant leukocyte Infiltration of the organs. In contrast to mild pancreatitis, ICAM-1 expression was increased at an earlier time point and systemically in severe necrotizing disease. Treatment with antibodies against ICAM-1 improved microcirculation and reduced local and systemic organ damage in severe pancreatitis.
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