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  • Title: Heterogeneity of the humoral anti-HCV/E2 response in persistently infected patients as demonstrated by divergent patterns of inhibition of the binding of anti-HCV/E2 human monoclonal antibodies.
    Author: Mancini N, Canducci F, Carletti S, Berardinelli E, Serafini G, Grieco A, Perotti M, Malcangi G, Danieli MG, Varaldo PE, Clementi M, Burioni R.
    Journal: J Biol Regul Homeost Agents; 2003; 17(2):183-7. PubMed ID: 14518720.
    Abstract:
    A complete understanding of the molecular features of humoral immune response could be of pivotal importance in the management of persistent viruses as HCV. In this study, 24 HCV-positive samples, characterized by classical virological parameters, are evaluated using a new assay for the quantitation of antibody subpopulations directed against discrete epitopes on surface glycoprotein E2, a key viral protein. The results, besides confirming the usefulness of this new approach, highlight the extreme heterogeneity of anti-HCV/E2 response as far as single epitopes are concerned. The specific epitopes under study are also demonstrated to be widely shared among different genotypes.
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