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  • Title: A high performance test of differential gene expression for oligonucleotide arrays.
    Author: Lemon WJ, Liyanarachchi S, You M.
    Journal: Genome Biol; 2003; 4(10):R67. PubMed ID: 14519202.
    Abstract:
    Logit-t employs a logit-transformation for normalization followed by statistical testing at the probe-level. Using four publicly-available datasets, together providing 2,710 known positive incidences of differential expression and 2,913,813 known negative incidences, performance of statistical tests were: Logit-t provided 75% positive-predictive value, compared with 5% for Affymetrix Microarray Suite 5, 6% for dChip perfect match (PM)-only, and 9% for Robust Multi-array Analysis at the p < 0.01 threshold. Logit-t provided 70% sensitivity, Microarray Suite 5 provided 46%, dChip provided 53% and Robust Multi-array Analysis provided 63%.
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