These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury.
    Author: Schmitt AB, Breuer S, Polat L, Pech K, Kakulas B, Love S, Martin D, Schoenen J, Noth J, Brook GA.
    Journal: Ann Neurol; 2003 Oct; 54(4):534-9. PubMed ID: 14520670.
    Abstract:
    Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time.
    [Abstract] [Full Text] [Related] [New Search]