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  • Title: [Indices of the lipid peroxidation--antioxidant defense system as markers of chronic cardiac failure in cardiomyopathies].
    Author: Volchegorskiĭ IA, Shaposhnik II, Alekseev EN, Kharchenkova NV.
    Journal: Klin Med (Mosk); 2003; 81(8):26-8. PubMed ID: 14520940.
    Abstract:
    Content of circulating products of lipid peroxidation (LPO), alpha-tocopherol (AT) and ceruloplasmin (CP), was studied in patients with hypertrophic and dilated cardiomyopathies (HTCMP and DCMP). The data obtained correlates with severity of chronic cardiac failure (CCF) and exercise tolerance of the patients. It is shown that the rise in LPO products level and simultaneous lowering of AT concentration in HTCMP and DCMP depend on the functional class of chronic cardiac failure by NYHA (1964). Content of lipoperoxides, AT and CP in the serum reflect the HTCMP patients' tolerance to exercise. Laboratory estimation of the levels of LPO products, AT and CP in patients with cardiomyopathies can substantially objectivize and supplement both clinical and functional-diagnostic assessment of CCF severity.
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