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  • Title: Alpha-synuclein oligomerization: a role for lipids?
    Author: Welch K, Yuan J.
    Journal: Trends Neurosci; 2003 Oct; 26(10):517-9. PubMed ID: 14522142.
    Abstract:
    Alpha-Synuclein is a core component of the proteinaceous aggregates observed in several neurodegenerative diseases. A central role of alpha-synuclein in neurodegeneration was demonstrated by the discovery of missense alpha-synuclein mutations in familial Parkinson's disease. However, the specific mechanism by which alpha-synuclein contributes to these diseases remains unclear. A recent study by Sharon et al. linked the presence of specific fatty acids to the appearance of alpha-synuclein oligomers in vivo. alpha-Synuclein oligomers might be a first step in the formation of alpha-synuclein aggregates present in a number of neurodegenerative diseases, although their cytotoxicity remains to be directly demonstrated.
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