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  • Title: Frequency of antigen-specific B cells during experimental ocular Chlamydia trachomatis infection.
    Author: Pal S, Taylor HR, Huneke RB, Prendergast RA, Whittum-Hudson JA.
    Journal: Infect Immun; 1992 Dec; 60(12):5294-7. PubMed ID: 1452363.
    Abstract:
    Chlamydia-specific antibody-secreting cells have been identified in conjunctiva and draining cervical lymph nodes by an ELISPOT assay in a cynomolgus monkey model of trachoma. These local sites contained numbers of chlamydia-specific B cells that were higher than those in distant inguinal lymph nodes and peripheral blood. The numbers of chlamydia-specific immunoglobulin G-secreting B cells observed were 5 to 57 per 10(6) cells in conjunctiva and 24 to 996 per 10(6) cells in cervical lymph nodes during conjunctival infection or after challenge of immune monkeys with the chlamydial 57-kDa heat shock protein (hsp60). These studies demonstrate a large chlamydia-specific B-cell component in the conjunctiva during ocular chlamydial infection. These results are similar to our findings for chlamydia-specific T-cell responses.
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