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  • Title: Kinesin motion in the absence of external forces characterized by interference total internal reflection microscopy.
    Author: Cappello G, Badoual M, Ott A, Prost J, Busoni L.
    Journal: Phys Rev E Stat Nonlin Soft Matter Phys; 2003 Aug; 68(2 Pt 1):021907. PubMed ID: 14525006.
    Abstract:
    We study the motion of the kinesin molecular motor along microtubules using interference total internal reflection microscopy. This technique achieves nanometer scale resolution together with a fast time response. We describe the first in vitro observation of kinesin stepping at high ATP concentration in the absence of an external load, where the 8-nm step can be clearly distinguished. The short-time resolution allows us to measure the time constant related to the relative motion of the bead-motor connection; we deduce the associated bead-motor elastic modulus.
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