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  • Title: A role for bacteriophage T4 rI gene function in the control of phage development during pseudolysogeny and in slowly growing host cells.
    Author: Los M, Wegrzyn G, Neubauer P.
    Journal: Res Microbiol; 2003 Oct; 154(8):547-52. PubMed ID: 14527655.
    Abstract:
    Although most studies on bacteriophages have been performed under laboratory conditions that are optimal for host cell growth, in nature, bacteria and bacteriophages coexist in different habitats. Here, by using different growth rates in carbon-limited chemostats, we investigated the development of phage T4 in its host Escherichia coli. Our results strongly suggest that T4 can form pseudolysogens not only when bacterial growth is completely inhibited, but also in growing host cells. The rI gene, previously known to be indispensable for lysis inhibition, seems to play an important role in optimization of phage development in slowly growing cells as well as during establishment and maintenance of pseudolysogeny.
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