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  • Title: [Morphine self-administration added to food conditioning: methodological variant in rats].
    Author: Leinot M, Basiez M, Roche F, Labrid C.
    Journal: C R Seances Soc Biol Fil; 1977; 171(4):796-803. PubMed ID: 145282.
    Abstract:
    Rats with permanent intra-jugular cannula are submitted to an alimentary operant reinforcement schedule with fixed ratio type FR 1, FR5, then FR 20. As a result, the animals are self administering (together with the alimentary inducer) a slow (about 5 sec) intravenous infusion of morphine (0.05 mg/kg). 20 per cent only of the experimental population exhibit a psychogenic dependance afterward. On the other hand, the animals for which morphine self-administration has been substituted to the alimentary reinforcement without respecting a transitory period combining both types of reinforcement have never shown any tendancy toward morphine self-administration. The lack of positive results could be related to the marked duration of the self-injection.
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