These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The microRNA-producing enzyme Dicer1 is essential for zebrafish development.
    Author: Wienholds E, Koudijs MJ, van Eeden FJ, Cuppen E, Plasterk RH.
    Journal: Nat Genet; 2003 Nov; 35(3):217-8. PubMed ID: 14528306.
    Abstract:
    MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.
    [Abstract] [Full Text] [Related] [New Search]