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  • Title: Proliferative activity of neokyotorphin-related hemoglobin fragments in cell cultures.
    Author: Sazonova OV, Blishchenko EY, Kalinina OA, Egorova NS, Surovoy AY, Philippova MM, Karelin AA, Ivanov VT.
    Journal: Protein Pept Lett; 2003 Aug; 10(4):386-95. PubMed ID: 14529492.
    Abstract:
    alpha-Hemoglobin fragments alpha-(133-141), alpha-(134-141), alpha-(135-141), alpha-(137-141), alpha-(134-140), alpha-(133-138), alpha-(134-140) and alpha-(137-138) stimulate L929 tumor cell proliferation, alpha-(134-141) being the most active. alpha-(134-141) stimulates proliferation of M3 melanoma cells, murine embryonic fibroblasts, primary cultures of red bone marrow and spleen cells. In L929 cells the effect of alpha-(134-141) is cell density independent; in M3 cells alpha-(137-141) and alpha-(134-141) are most active at density 10,000 cells/well (96 well plate) independently on FBS content.
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