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  • Title: [Association of distal tubular acidosis, Hashimoto's thyroiditis and Gougerot-Sjögren's syndrome].
    Author: Bouchhima C, Mnif M, Jarraya F, Rekik N, Hachicha J, Abid M.
    Journal: Presse Med; 2003 Sep 20; 32(30):1410-2. PubMed ID: 14534487.
    Abstract:
    INTRODUCTION: Distal tubular acidosis is associated with auto-immune diseases not specific to organ. The coexistence of distal tubular acidosis and auto-immune thyroid affection is very rare. OBSERVATION: A 36-year-old woman exhibiting primary hypothyroidism, Gougerot-Sjögren's syndrome and hypergammaglobulinemia, presented distal tubular acidosis revealed by severe hypokaliemia and complicated by quadriplegia and circulatory arrest. Correcting the thyroid defect did not appear to influence the progression of acidosis. COMMENTS: Based on this observation, one can discuss the pathogenesis of distal tubular acidosis during auto-immune diseases (hypothyroidism, Gougerot-Sjögren's syndrome and monoclonal hypergammaglobulinemia) and its impact on therapy.
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