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  • Title: [Study on anti-tumor activity of extracts from cultured cells of Taxus chinensis].
    Author: Lu C, Mei X.
    Journal: Zhong Yao Cai; 2003 May; 26(5):335-7. PubMed ID: 14535014.
    Abstract:
    OBJECTIVE: To analyze the cytotoxicity and inhibitory effect of extracts from cultured cells(from stems) of Taxus chinensis on cancer cell line SMMC-7721. METHODS: MTT assay for cell viability and flow cytometry for cell cycle analysis. RESULTS: MTT results showed that the extact by dichloromethane was more effective than that by methanol on SMMC-7721, IC50 were 0.0834 mg DCW.ml-1 and 0.8002 mg DCW.ml-1 respectively. SMMC-7721 cells in G2-M stage increased with higher concentration of dichloromethane extracts from Taxus chinensis cells and longer incubation. CONCLUSION: Extracts from cultured cells of Taxus chinensis could have cytotoxic effect on SMMC-7721 and could induce apoptosis of cancer cells.
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