These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A facile asymmetric route to (-)-aphanorphine.
    Author: Zhai H, Luo S, Ye C, Ma Y.
    Journal: J Org Chem; 2003 Oct 17; 68(21):8268-71. PubMed ID: 14535817.
    Abstract:
    8O-methylaphanorphine was synthesized from 4-methoxyphenylacetaldehyde in 36% overall yield and in nine steps, featuring the formation of ring B via a Friedel-Crafts alkylative cyclization with the concomitant stereospecific introduction of the benzylic quaternary carbon center. The current work constitutes an efficient enantioselective formal synthesis of 3-benzazepine marine alkaloid (-)-aphanorphine.
    [Abstract] [Full Text] [Related] [New Search]