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  • Title: Combination drug therapy in treatment of Paget's disease of bone: clinical and metabolic response.
    Author: Hadjipavlou AG, Tsoukas GM, Siller TN, Danais S, Greenwood F.
    Journal: J Bone Joint Surg Am; 1977 Dec; 59(8):1045-51. PubMed ID: 145441.
    Abstract:
    Twenty-seven patients with symptomatic Paget's disease of bone were randomly treated with mithramycin, glucagon, and calcitonin given either alone or in combination. Mithramycin, at a dose of fifteen micrograms per kilogram of body weight per day, proved to be a relatively safe drug and elicited a rapid response with only transient side effects. Calcitonin combined with mithramycin was the most effective therapy.
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