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  • Title: Positive and negative selection of T cell repertoires during differentiation in allogeneic bone marrow chimeras.
    Author: Onoé K, Gotohda T, Nishihori H, Aranami T, Iwabuchi C, Iclozan C, Morohashi T, Ogasawara K, Good RA, Iwabuchi K.
    Journal: Transpl Immunol; 2003; 12(1):79-88. PubMed ID: 14551035.
    Abstract:
    T cells acquire immune functions during expansion and differentiation in the thymus. Mature T cells respond to peptide antigens (Ag) derived from foreign proteins when these peptide Ag are presented on the self major histocompatibility complex (MHC) molecules but not on allo-MHC. This is termed self-MHC restriction. On the other hand, T cells do not induce aggressive responses to self Ag (self-tolerance). Self-MHC restriction and self-tolerance are not genetically determined but acquired a posteriori by positive and negative selection in the thymus in harmony with the functional maturation. Allogeneic bone marrow (BM) chimera systems have been a useful strategy to elucidate mechanisms underlying positive and negative selection. In this communication, the contribution of BM chimera systems to the investigation of the world of T-ology is discussed.
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