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  • Title: A Neurexin-related protein, BAM-2, terminates axonal branches in C. elegans.
    Author: Colavita A, Tessier-Lavigne M.
    Journal: Science; 2003 Oct 10; 302(5643):293-6. PubMed ID: 14551437.
    Abstract:
    Neuronal axons connect to multiple target cells through the formation of collateral branches, but the mechanisms that regulate this process are largely unknown. We show that BAM-2, a neurexin-related transmembrane protein, is required for development of VC motoneuron branches in the worm Caenorhabditis elegans. Expression analysis and ectopic expression experiments suggest that BAM-2 functions as a branch termination cue and reveal a mechanism for selective control of branches that sprout off a primary axon.
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