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Pubmed for Handhelds

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  • Title: Phosphodiesterase type 5 inhibitors: a biochemical and clinical correlation survey.
    Author: Kim NN.
    Journal: Int J Impot Res; 2003 Oct; 15 Suppl 5():S13-9. PubMed ID: 14551572.
    Abstract:
    Phosphodiesterase type 5 (PDE 5) is the major cGMP hydrolyzing enzyme in penile corpus cavernosum and is an important regulator of nitric oxide-mediated smooth muscle relaxation. The critical role of PDE 5 in penile erection and the recent availability of specific and potent inhibitors of PDE 5 have enabled the development of effective oral treatment strategies that have been widely accepted by both health-care professionals and the lay public. This article examines the correlation between the available biochemical and clinical data for the PDE 5 inhibitors sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra).
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