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  • Title: No evidence for association between the polymorphism in the 3' untranslated region of interleukin-12B and human susceptibility to tuberculosis.
    Author: Ma X, Reich RA, Gonzalez O, Pan X, Fothergill AK, Starke JR, Teeter LD, Musser JM, Graviss EA.
    Journal: J Infect Dis; 2003 Oct 15; 188(8):1116-8. PubMed ID: 14551880.
    Abstract:
    Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3' untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3' UTR has no effect or has a negligible effect on human susceptibility to TB.
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