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  • Title: [Effect of endotoxemia on thyrotropin releasing hormone and its receptor in Wistar rat brain].
    Author: Wang XC, Liu BY, Xu P, Jing H.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2003 Oct; 15(10):622-4. PubMed ID: 14552689.
    Abstract:
    OBJECTIVE: To study the dose and location of thyrotropin releasing hormone (TRH) and its receptor in Wistar rat's brain when early endotoxemia happened. METHODS: Twenty-two Wistar rats were selected. In 13 mouse the model was established with endotoxemia and hemorrhagic shock. The TRH and its receptor were observed with radioimmunoassay (RIA), and were compared to the 9 control rats. RESULTS: The dose of TRH decreased significantly in the early stage of endotoxemia. The maxium dose (Bmax) of TRH increased while Kd (affinity) decreased, so the effective TRH receptor had no significantly change. CONCLUSION: The dose of TRH is different in brain and serum. The decrease of TRH and the steady of active TRH receptor may protect the brain tissue and repress multiple organ dysfunction syndrome (MODS) in the early stage of endotoxemia.
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