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  • Title: Spongiform encephalopathy in a captive puma (Felis concolor).
    Author: Willoughby K, Kelly DF, Lyon DG, Wells GA.
    Journal: Vet Rec; 1992 Nov 07; 131(19):431-4. PubMed ID: 1455592.
    Abstract:
    A captive adult puma developed ataxia, a hypermetric gait and whole body tremor. The signs progressed over a period of six weeks. Histopathological examination following euthanasia demonstrated spongiform encephalopathy, gliosis and mild non-suppurative meningoencephalitis. Immunostaining with a polyclonal antiserum revealed prion protein (PrP) associated with these changes in sections of cervical spinal cord and medulla. This is the first confirmed case of a scrapie-like spongiform encephalopathy described in a non-domestic cat in the United Kingdom.
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