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  • Title: [Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease].
    Author: Su JJ, Xie HJ, Zhao WW, Han HX, Gao T, Xu L, Tang GM, Ren DM.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2003 Oct; 20(5):444-6. PubMed ID: 14556204.
    Abstract:
    OBJECTIVE: To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area. METHODS: Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls. RESULTS: The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association. CONCLUSION: These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.
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