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  • Title: Kinetics of hydrolysis of diltiazem hydrochloride in aqueous solutions.
    Author: Muszalska I, Jamszoł L, Grześkowiak D.
    Journal: Acta Pol Pharm; 2003; 60(3):163-8. PubMed ID: 14556482.
    Abstract:
    The kinetics of hydrolysis of diltiazem hydrochloride in aqueous solutions at 313, 323, 333 and 353 K over the pH-range 0.4-9.7 has been investigated. The decomposition was followed by the HPLC method. The pH-rate profile was accounted for by the specific acid- and base-catalysed reactions and also by assuming spontaneous or water-catalysed decomposition of both dissociated and undissociated molecules of diltiazem. Various buffer substances were found to exhibit general acid and base catalysis of the degradation. Thermodynamic parameters of the reaction: energy and enthalpy of activation and the frequency factor for the specific rate constants were determined.
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