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  • Title: A fatal case of West Nile virus infection in a bone marrow transplant recipient.
    Author: Hiatt B, DesJardin L, Carter T, Gingrich R, Thompson C, de Magalhaes-Silverman M.
    Journal: Clin Infect Dis; 2003 Nov 01; 37(9):e129-31. PubMed ID: 14557983.
    Abstract:
    West Nile virus (WNV) can cause severe, potentially fatal neurological illnesses, which include encephalitis, meningitis, Guillain-Barré syndrome, and anterior myelitis. Because of the short viremic phase, WNV infection is most commonly diagnosed by detection of immunoglobulin M antibody to WNV in serum or cerebrospinal fluid (CSF). We describe a patient with T cell lymphoma who had undergone a T cell-depleted bone marrow transplantation and developed fatal WNV infection. The results of serological tests of blood samples and of CSF tests were negative. Diagnosis was made postmortem by a positive result of reverse-transcriptase polymerase chain reaction (ABI 7700; TaqMan) for WNV in stored CSF and serum samples.
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