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  • Title: Rat liver transplantation for total vascular reconstruction, using a suture method.
    Author: Inoue S, Tahara K, Shimizu H, Yoshino H, Suzuki C, Kaneko T, Hakamata Y, Takahashi M, Murakami T, Kaneko M, Kobayashi E.
    Journal: Microsurgery; 2003; 23(5):470-5. PubMed ID: 14558005.
    Abstract:
    We developed a novel protocol for rat orthotopic liver transplantation (OLT), using a suture method to establish hepatic artery flow. After determining that early inferior vena cava (IVC) unclamping maintained better circulation compared with the portal vein (PV) using porto-systemic shunted recipients, we developed a rat OLT model with total vascular reconstruction using a suture method. After connecting the suprahepatic IVC, the infrahepatic IVC was anastomosed, using a running suture method. IVC circulation was established immediately. The PV was anastomosed without intestinal congestion, using porto-systemic shunted recipients. The aortic conduit, including the donor celiac and hepatic artery, was anastomosed to the recipient abdominal aorta end-to-side. Eight of 11 OLT cases (72.7%) survived indefinitely. Biliary connection was achieved using a one-stent method. Three cases died 3-5 days postoperatively. Hepatic angiography showed good patency. The graft liver was histologically normal in long-surviving rats.
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