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  • Title: Effects of thalidomide on parameters involved in angiogenesis: an in vitro study.
    Author: Gelati M, Corsini E, Frigerio S, Pollo B, Broggi G, Croci D, Silvani A, Boiardi A, Salmaggi A.
    Journal: J Neurooncol; 2003 Sep; 64(3):193-201. PubMed ID: 14558594.
    Abstract:
    In an attempt to elucidate the mechanism(s) of action of thalidomide, a reportedly antiangiogenic molecule recently tested in the treatment of relapsing malignant gliomas, we performed an in vitro study on the following parameters: (a) effect of thalidomide on proliferation of endothelial cells; (b) effect of thalidomide on expression of alpha(v)beta3 integrin on the surface of endothelial cells; (c) effect of thalidomide on the release by endothelial cells of MMP-2, IL-8 and TNF-alpha. The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug. On the other hand, thalidomide does not modify expression of alpha(v)beta3 on endothelial cells.
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