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  • Title: [Association of receptor-mediated endocytosis and autophagy with apoptosis].
    Author: He CG, Piao YJ, Hu LM.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2003 Oct; 23(10):1025-7. PubMed ID: 14559683.
    Abstract:
    OBJECTIVE: To evaluate the relationship between receptor-mediated endocytosis, autophagosome formation and apoptosis by observing the morphological changes of mouse peritoneal macrophages in the course of receptor-mediated endocytotic activities, autophagy and apoptosis. METHODS: Mouse peritoneal macrophages were incubated with horseradish peroxidase-labeled concanavalin A (ConA-HRP), and morphological examinations were performed at different time points after the incubation. RESULTS: After the incubation of the macrophages with ConA-HRP, ConA-HRP was observed to enter the vesicles by way of receptor-mediated endocytosis. Three kinds of endosomes were observed, namely vesicles, tubes and double-membrane sheets. The double-membrane sheets enveloped a portion of the cytoplasm and organelles, thus giving rise to vesicles, or the autophagosomes, which later fused with lysosome, followed by the apoptosis of the macrophages. CONCLUSION: Receptor-mediated endocytosis of ConA-HRP is associated with autophagy and apoptosis.
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