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  • Title: Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death.
    Author: Barnes BJ, Kellum MJ, Pinder KE, Frisancho JA, Pitha PM.
    Journal: Cancer Res; 2003 Oct 01; 63(19):6424-31. PubMed ID: 14559832.
    Abstract:
    We have previously shown a critical role for IFN regulatory factor 5 (IRF-5) in the innate immune response to virus infection. For the first time, we now show that although IRF-5 is a direct target of p53, its cell cycle regulatory and proapoptotic effects are p53 independent. IRF-5 inhibits both in vitro and in vivo B-cell lymphoma tumor growth in the absence of wild-type p53. The molecular mechanism(s) of IRF-5-mediated growth inhibition is associated with a G(2)-M cell cycle arrest and modulation of growth regulatory and proapoptotic genes, including p21, Bak, DAP kinase 2, and Bax. Taken together, these data indicate that although IRF-5 is a downstream target of p53, its growth inhibitory and proapoptotic effects are independent of p53.
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