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  • Title: Effect of dizocilpine maleate on cerebral anoxia and ischemic damage in rodents.
    Author: Ping HX, Su J, Liu H, Liu GQ, Xie L, Wu HQ.
    Journal: Zhongguo Yao Li Xue Bao; 1992 Jul; 13(4):315-8. PubMed ID: 1456051.
    Abstract:
    The Protective effects of dizocilpine maleate (DM) against anoxia in mice and ischemic damage in rats of 4-vessel occlusion (4-VO) were studied. DM 0.5 or 1.0 mg.kg-1 ip significantly prolonged the survival time of mice in closed containers. DM 0.5 and 1.0 mg.kg-1 ip 30 min prior to 4-VO obviously accelerated the electroencephalographic recovery, reduced the neuronal loss in the hippocampus, and increased the survival rate after 72-h reperfusion. These effects followed a dose-dependent manner. Our results indicate that selective non-competitive N-methyl-D-aspartate receptor blocker DM protects against anoxic and ischemic cerebral damage.
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