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  • Title: [Effect of mexiletine on energy metabolism of ischemic brain in mice].
    Author: Dong LP, Wang TY, Zhang L.
    Journal: Zhongguo Yao Li Xue Bao; 1992 Jul; 13(4):354-6. PubMed ID: 1456059.
    Abstract:
    After 30 s ischemia induced by decapitation, the contents of ATP and phosphocreatine (PC) in mouse brain reduced, while that of lactic acid (LA) increased. When mexiletine (3.1-50 mg.kg-1) was injected ip 30 min before decapitation, the brain ATP and PC reduction, and LA accumulation were both alleviated in a dose-dependent manner. These findings suggested that mexiletine was effective in ameliorating the energy exhaustion in the ischemic brain.
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